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ProductsBack/beta-Glucuronide-dPBD-PEG5-NH2 (TFA) [2246364-63-4]

beta-Glucuronide-dPBD-PEG5-NH2 (TFA) [2246364-63-4]

HY-145736A
MedChem Express
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Product group Molecular Biology
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Overview

  • Supplier
    MedChem Express
  • Product Name
    beta-Glucuronide-dPBD-PEG5-NH2 (TFA) [2246364-63-4]
  • Delivery Days Customer
    10
  • CAS Number
    2246364-63-4
  • Certification
    Research Use Only
  • Molecular Formula
    C80H102F3N7O37
  • Molecular Weight
    1810.69
  • Scientific Description
    beta-Glucuronide-dPBD-PEG5-NH2 TFA is the beta-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.beta-glucuronide-linkage as a cleavable linker. beta-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. beta-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. beta-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity[1].
  • SMILES
    NOCCOCCOCCOCCOCCOCCNC(C(C=C1COC(N2C3=CC(OCCCCCOC4=C(OC)C=C(C(N5[C@](CC(C5)=C)([H])C(N6C(OCC7=CC(C(NCCOC)=O)=C(C=C7)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=O)O)=O)C6=C4)=C(OC)C=C3C(N9[C@](CC(C9)=C)([H])C2O)=O)=O)=C(C=C1)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)C(O)=O)=O.OC(C(F)(F)F)=O
  • UNSPSC
    41115800