ProductsBack/beta-Glucuronide-dPBD-PEG5-NH2 (TFA) [2246364-63-4]

beta-Glucuronide-dPBD-PEG5-NH2 (TFA) [2246364-63-4]

Name: beta-Glucuronide-dPBD-PEG5-NH2 (TFA) [2246364-63-4]
SKU: HY-145736A_M09
Availability: BackOrder

HY-145736A

Product group Molecular Biology

Overview

Supplier
MedChem Express
Product Name
beta-Glucuronide-dPBD-PEG5-NH2 (TFA) [2246364-63-4]
Delivery Days Customer
10
CAS Number
2246364-63-4
Certification
Research Use Only
Molecular Formula
C80H102F3N7O37
Molecular Weight
1810.69
Scientific Description
beta-Glucuronide-dPBD-PEG5-NH2 TFA is the beta-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate (ADC) cIRCR201-dPBD.beta-glucuronide-linkage as a cleavable linker. beta-Glucuronide-dPBD-PEG5-NH2 TFA, as a proagent of cIRCR201-dPBD, reduces side effects. beta-Glucuronide-dPBD-PEG5-NH2 TFA can induce apoptosis and arrest cell cycle. beta-Glucuronide-dPBD-PEG5-NH2 TFA has antitumor activity[1].
SMILES
NOCCOCCOCCOCCOCCOCCNC(C(C=C1COC(N2C3=CC(OCCCCCOC4=C(OC)C=C(C(N5[C@](CC(C5)=C)([H])C(N6C(OCC7=CC(C(NCCOC)=O)=C(C=C7)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=O)O)=O)C6=C4)=C(OC)C=C3C(N9[C@](CC(C9)=C)([H])C2O)=O)=O)=C(C=C1)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)C(O)=O)=O.OC(C(F)(F)F)=O
UNSPSC
41115800