beta-S-ARCA

MedChem Express

beta-S-ARCA [1093268-63-3]

10

Research Use Only

C22H31N10O17P3S

832.52

beta-S-ARCA is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating beta-S-ARCA have elongated cellular half-lives and showed augmented protein expression. beta-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines[1].

O=P(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)OP(OP(OC[C@@H]4[C@@H](O)[C@@H](OC)[C@H](N5C(NC(N)=N6)=C([N+](C)=C5)C6=O)O4)([O-])=O)(S)=O

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