beta,beta-Dimethylacrylshikonin [24502-79-2]

TargetMol Chemicals

beta,beta-Dimethylacrylshikonin [24502-79-2]

9

24502-79-2

Chemical

Research Use Only

bèta,bèta-Dimethylacrylshikonin

98.86%

C21H22O6

370.4

1. beta,beta-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft. (b) Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 . (c) Dimethylacrylshikonin inhibited growth of gastric cancer SGC-791 cells by inducing ERK signaling pathway. 2. Dimethylacrylshikonin inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-kappaB pathway.

3 years

CC(C)=CCC(OC(=O)C=C(C)C)C1=CC(=O)c2c(O)ccc(O)c2C1=O

-20°C

12352200