Betulinic acid [472-15-1]

Chemodex

Betulinic acid [472-15-1]

10

472-15-1

Research Use Only

>98%

C30H48O3

456.71

Betulinic acid is a natural plant triterpenoid. It has been shown to have anticancer, apoptotic, anti-inflammatory, antiobesity, antimalarial and anti-HIC properties. It has been described as a potent DNA topoisomerase II inhibitor and proteasome activator. It is an agonist of the G protein-coupled bile acid receptor TGR5, which might be linked with its ability to alter gene expression and fatty liver development. Betulinic acid also reduces NF-kappa signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1. - Chemical. CAS: 472-15-1. Formula: C30H48O3. MW: 456.71. Betulinic acid is a natural plant triterpenoid. It has been shown to have anticancer, apoptotic, anti-inflammatory, antiobesity, antimalarial and anti-HIC properties. It has been described as a potent DNA topoisomerase II inhibitor and proteasome activator. It is an agonist of the G protein-coupled bile acid receptor TGR5, which might be linked with its ability to alter gene expression and fatty liver development. Betulinic acid also reduces NF-kappa signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1.

O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@]2([H])CC[C@@]4([H])[C@@]3(C)CC[C@]5(C(O)=O)[C@]4([H])[C@H](C(C)=C)CC5)([H])C1(C)C

2°C to 8°C,RT

12352200