Bexotegrast [2376257-44-0]

MedChem Express

Bexotegrast [2376257-44-0]

10

2376257-44-0

Research Use Only

98.09

C27H36N6O3

492.61

Bexotegrast (PLN-74809) is an orally active, potent dual alphavbeta6/alphavbeta1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits alphavbeta6- and alphavbeta1-induced TGF-beta activation with IC50 values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-beta activation in the fibrotic lung[1][2].

OC([C@H](CCN(CCOC)CCCCC(N1)=CC=C2C1=NCCC2)NC3=NC=NC4=C3C=CC=C4)=O

2°C to 8°C

12352200