BF-170 [22191-97-5]

MedChem Express

BF-170 [22191-97-5]

5

22191-97-5

Research Use Only

C15H12N2

220.27

BF-170 is a selective tau fibril binding agent with an EC50 of 221 nM. It exhibits good blood-brain barrier permeability, and after intravenous injection in mice, the concentration in brain tissue reaches 9.1% ID/g within 2 minutes (with a brain clearance rate of 0.25% ID/g after 30 minutes). BF-170 can be used as a probe for tau protein pathology imaging in Alzheimers disease (AD). It plays an important role in early-stage AD research and holds potential for imaging studies of tau-related neurodegenerative diseases[1].

C1=CC=C2C(=C1)C=CC(=N2)C3=CC=C(C=C3)N

12352200