BHLHE40 Antibody

Cusabio

BHLHE40 Antibody

20

ImmunoFluorescence, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

BHLHE40

basic helix-loop-helix family member e40

BHLHB2, Clast5, DEC1, HLHB2, SHARP-2, SHARP2, STRA13, Stra14, class E basic helix-loop-helix protein 40, basic helix-loop-helix domain containing, class B, 2, class B basic helix-loop-helix protein 2, differentially expressed in chondrocytes 1, differentially expressed in chondrocytes protein 1, differentiated embryo chondrocyte expressed gene 1, enhancer-of-split and hairy-related protein 2, stimulated by retinoic acid gene 13 protein

Rabbit

IgG

Class E basic helix-loop-helix protein 40

Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 - ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5-CACGTG-3) found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.

Human

-20°C or -80°C

41116161