BI-0474 [2750570-55-7]

MedChem Express

BI-0474 [2750570-55-7]

5

2750570-55-7

Research Use Only

99.83

C30H37N9O2S

587.74

BI-0474 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models[1].

N#CC1=C(N)SC2=C1[C@@](C)(C3=NC(C4=NC(N5[C@@H](C)CN(C)CC5)=CC(N6CCN(C(C=C)=O)CC6)=C4)=NO3)CCC2

-20°C,2°C to 8°C

12131703