Chemical Structure
Chemical Structure
BI-2536 [755038-02-9]
82062
CAS Number755038-02-9
Product group Chemicals
Estimated Purity≥95%
Molecular Weight521.7 Da
Overview
- SupplierBPS Bioscience
- Product NameBI-2536
- Delivery Days Customer7
- CAS Number755038-02-9
- CertificationResearch Use Only
- Estimated Purity≥95%
- Molecular FormulaC28H39N7O3
- Molecular Weight521.7 Da
- Scientific DescriptionBI-2536 is a potent, ATP-competitive, well tolerated and effects Polo-like kinases (Plks) as well as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. BI-2536 has an IC50 of 0.83 and 25 nM with PLK1 and BRD4 inhibitor, respectively. BI-2536 also blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. BI-2536 suppresses IFNB (encoding IFN-Y) gene transcription. It also shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells.
- Storage Instruction-20°C
- UNSPSC51202000
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