BI-2536

BPS Bioscience

BI-2536

7

755038-02-9

Research Use Only

95%

C28H39N7O3

521.7 Da

BI-2536 is a potent, ATP-competitive, well tolerated and effects Polo-like kinases (Plks) as well as a pan-BET (bromodomain and extra-terminal motif) family inhibitor. BI-2536 has an IC50 of 0.83 and 25 nM with PLK1 and BRD4 inhibitor, respectively. BI-2536 also blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. BI-2536 suppresses IFNB (encoding IFN-Y) gene transcription. It also shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells.

-20°C

12352200