BI 653048

MedChem Express

BI 653048 [1198784-72-3]

10

1198784-72-3

Research Use Only

99.84

C23H25F4N3O4S

515.52

BI 653048 is a selective and orally active nonsteroidal? glucocorticoid (GC) ?agonist with an IC 50 value of 55 nM [1] . BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms activity and reduces affinity for the hERG ion channel ( IC 50 >30 microM) [2] . BI 653048 is extracted from patent WO2005028501A1 (Compound 103), is also a? HCV NS3 protease ?inhibitor that can reduce viral loads infected with the?hepatitis C?virus [3] .

O=C(N)C1=CC(F)=CC=C1C(C)(C)C[C@@](O)(CC(N2)=CC3=C2C=NC(S(=O)(CC)=O)=C3)C(F)(F)F

-20°C,2°C to 8°C

12352200