BI-749327 [2361241-23-6]

MedChem Express

BI-749327 [2361241-23-6]

10

2361241-23-6

Research Use Only

98.49%

C23H21F3N4O2

442.43

BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7.

NC1=NN=C(C2CCN(C(C3=CC=C(OC4=CC=C(C(F)(F)F)C=C4)C=C3)=O)CC2)C=C1

2°C to 8°C,-20°C,-80°C

12352200