BI-882370

MedChem Express

BI-882370 [1392429-79-6]

10

1392429-79-6

Research Use Only

99.16

C28H33F2N7O2S

569.67

BI-882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG-out (inactive) conformation of the BRAF kinase. BI-882370 (BI 882370) inhibits the oncogenic BRAF V600E -mutant, the WT BRAF and CRAF kinases with IC 50 s of 0.4, 0.8, and 0.6 nM, respectively. BI-882370 also inhibits SRC family kinases [1] .

CCCS(=O)(NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C4=NC(N(C5CCN(CC)CC5)C)=CC=C42)=C1F)=O

-20°C,2°C to 8°C

12352200