Chemical Structure
Chemical Structure
BI-9564
82064
CAS Number1883429-22-8
Product group Chemicals
Molecular Weight353.4 Da
Overview
- SupplierBPS Bioscience
- Product NameBI-9564
- Delivery Days Customer7
- CAS Number1883429-22-8
- CertificationResearch Use Only
- Molecular FormulaC20H23N3O3
- Molecular Weight353.4 Da
- Scientific DescriptionBI-9564 inhibits BRD9 and BRD7 bromodomains and exhibits no significant off-target pharmacology against a panel of 324 kinases and 55 GPCRs at concentrations less than 5 microM. BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 microM, respectively) that demonstrates cellular activity by semi-quantitative FRAP assay with ~90% inhibition of BRD9 and BRD7 at 0.1 microM and 1 microM, respectively. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo.
- Storage Instruction-20°C
- UNSPSC12352200
