BI8622 [1875036-74-0]

MedChem Express

BI8622 [1875036-74-0]

10

1875036-74-0

Research Use Only

99.35

C25H26N6O

426.51

BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 microM. BI8622 can decrease the protein expression levels of c-myc and glycolytic markers as well as immune modulatory markers after HUWE1 inhibition in triple-negative breast cancer (TNBC) cell lines. BI8622 significantly protects against cisplatin (HY-17394)-induced acute kidney injury (AKI). BI8622 significantly reduces the growth of multiple myeloma (MM) cell lines and induces cell cycle arrest. BI8622 can prevent HUWE1-dependent TTBK2 ubiquitination. BI8622 can be studied in research for various diseases including medulloblastoma, acute kidney injury, breast cancer and MM[1][2][3][4][5].

O=C(C1=NC=NC(N2CCC(C3=CC=CC=C3)(C#N)CC2)=C1C)NC4=CC=C(CN)C=C4

-20°C,2°C to 8°C

12352200