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ProductsBack/Bilobalide [33570-04-6]
Chemical Structure
Chemical Structure
Chemical Structure

Bilobalide [33570-04-6]

Research Use Only
AG-CN2-0026
AdipoGen Life Sciences
CAS Number33570-04-6
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight326.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Bilobalide [33570-04-6]
  • Delivery Days Customer
    10
  • CAS Number
    33570-04-6
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C15H18O8
  • Molecular Weight
    326.3
  • Scientific Description
    Chemical. CAS: 33570-04-6. Formula: C15H18O8. MW: 326.3. Isolated from Ginko biloba. Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway. Potent anti-inflammatory and antihyperalgesic agent. - Neuroprotective [2, 3, 4, 5, 7]. Mitochondrial gene expression regulator [3]. ROS scavenger [4]. Competitive GABA(A) receptor antagonist [6]. Apoptosis inhibitor [4, 7, 10, 11]. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis [8]. Hepatic cytochrome P450 inducer [9]. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway [10, 11]. Potent anti-inflammatory and antihyperalgesic agent [12].
  • SMILES
    CC(C)(C)[C@]1(O)C[C@@H]2OC(=O)C[C@@]22C(=O)O[C@@H]3OC(=O)[C@H](O)C123
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Bilobalid A, ein neues Sesquiterpen mit tert.-Butyl-Gruppe aus den Blättern von Ginkgo biloba L.: K. Weinges & W. Bähr; Liebigs Ann. Chem. 724, 214 (1969)
  • Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide: D. Janssens, et al.; Biochem. Pharmacol. 50, 991 (1995)
  • Protection of mitochondrial respiration activity by bilobalide: D. Janssens, et al.; Biochem. Pharmacol. 58, 109 (1999)
  • Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide: L.J. Zhou & X.Z. Zhu; J. Pharmacol. Exp. Ther. 293, 982 (2000)
  • Bilobalide and neuroprotection: F.V. Defeudis; Pharmacol. Res. 46, 565 (2002) (Review)
  • Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors: S.H. Huang, et al.; Eur. J. Pharmacol. 464, 1 (2003)
  • Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death: K. Chandrasekaran, et al.; Pharmacopsychiatry 36 Suppl 1, S89 (2003)
  • Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons: F. Tchantchou, et al.; J. Alzheimers Dis. 18, 787 (2009)
  • Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats: Y. Taki, et al.; J. Pharmacol. Sci. 109, 459 (2009)
  • Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells: C. Shi, et al.; Apoptosis 15, 715 (2010)