Chemical Structure
Bilobalide [33570-04-6]
AG-CN2-0026
Overview
- SupplierAdipoGen Life Sciences
- Product NameBilobalide
- Delivery Days Customer10
- CAS Number33570-04-6
- CertificationResearch Use Only
- Estimated Purity>95%
- Molecular FormulaC15H18O8
- Molecular Weight326.3
- Scientific DescriptionChemical. CAS: 33570-04-6. Formula: C15H18O8. MW: 326.3. Isolated from Ginko biloba. Neuroprotective. Mitochondrial gene expression regulator. ROS scavenger. Competitive GABA(A) receptor antagonist. Apoptosis inhibitor. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis. Hepatic cytochrome P450 inducer. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway. Potent anti-inflammatory and antihyperalgesic agent. - Neuroprotective [2, 3, 4, 5, 7]. Mitochondrial gene expression regulator [3]. ROS scavenger [4]. Competitive GABA(A) receptor antagonist [6]. Apoptosis inhibitor [4, 7, 10, 11]. CREB phosphorylation enhancer. Stimulates neurogenesis and synaptogenesis [8]. Hepatic cytochrome P450 inducer [9]. Activates the phosphatidylinositol 3-kinase (PI3K) dependent pathway [10, 11]. Potent anti-inflammatory and antihyperalgesic agent [12].
- SMILESCC(C)(C)[C@]1(O)C[C@@H]2OC(=O)C[C@@]22C(=O)O[C@@H]3OC(=O)[C@H](O)C123
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200
References
- Bilobalid A, ein neues Sesquiterpen mit tert.-Butyl-Gruppe aus den Blättern von Ginkgo biloba L.: K. Weinges & W. Bähr; Liebigs Ann. Chem. 724, 214 (1969)
- Protection of hypoxia-induced ATP decrease in endothelial cells by ginkgo biloba extract and bilobalide: D. Janssens, et al.; Biochem. Pharmacol. 50, 991 (1995)
- Protection of mitochondrial respiration activity by bilobalide: D. Janssens, et al.; Biochem. Pharmacol. 58, 109 (1999)
- Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide: L.J. Zhou & X.Z. Zhu; J. Pharmacol. Exp. Ther. 293, 982 (2000)
- Bilobalide and neuroprotection: F.V. Defeudis; Pharmacol. Res. 46, 565 (2002) (Review)
- Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors: S.H. Huang, et al.; Eur. J. Pharmacol. 464, 1 (2003)
- Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death: K. Chandrasekaran, et al.; Pharmacopsychiatry 36 Suppl 1, S89 (2003)
- Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons: F. Tchantchou, et al.; J. Alzheimers Dis. 18, 787 (2009)
- Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats: Y. Taki, et al.; J. Pharmacol. Sci. 109, 459 (2009)
- Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells: C. Shi, et al.; Apoptosis 15, 715 (2010)