Bimatoprost isopropyl ester

MedChem Express

Bimatoprost isopropyl ester [130273-87-9]

5

130273-87-9

Research Use Only

C26H38O5

430.58

15(R)-17-phenyl trinor Prostaglandin F2alpha isopropyl ester (15(R)-17-phenyl trinor PGF2alpha isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (beta) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2alpha isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC 50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2alpha and 15(R)-17-phenyl trinor PGF2alpha were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 microg dose of 15(R)-17-phenyl trinor PGF2alpha caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.

O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@H](O)CCC2=CC=CC=C2)[C@H](O)C[C@@H]1O

12352200