BIRC3 Antibody

Cusabio

BIRC3 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

BIRC3

baculoviral IAP repeat containing 3

AIP1; API2; apoptosis inhibitor 2; baculoviral IAP repeat-containing protein 3; cellular inhibitor of apoptosis 2; CIAP2; c-IAP2; HAIP1; HIAP1; IAP homolog C; IAP-1; inhibitor of apoptosis protein 1; MALT2; mammalian IAP homolog C; MIHC; RING finger protein 49; RING-type E3 ubiquitin transferase BIRC3; RNF49; TNFR2-TRAF signaling complex protein; TNFR2-TRAF-signaling complex protein 1

Rabbit

IgG

Baculoviral IAP repeat-containing protein 3

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.

Human, Mouse

-20°C or -80°C

41116161