BIX-01294

MedChem Express

BIX-01294 [935693-62-2]

5

935693-62-2

98.44

C28H38N6O2

490.64

BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC 50 s of of 1.7 microM and 0.9 microM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy . BIX-01294 has antitumor activity in recurrent tumor cells [1] [2] [3] [4] [5] .

COC1=C(OC)C=C(C(NC2CCN(CC3=CC=CC=C3)CC2)=NC(N4CCN(C)CCC4)=N5)C5=C1

-20°C,2°C to 8°C

12352200