BIX02188 (BIX 02188)

Biorbyt

BIX02188 (BIX 02188) [334949-59-6]

16

334949-59-6

Research Use Only

C25H24N4O2

412.48366

BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

O=C(N)C1=CC(NC2=O)=C(/C2=C(C3=CC=CC=C3)/NC4=CC=CC(CN(C)C)=C4)C=C1

12352200