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P07204

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Bio-Connect Life Sciences

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RP_SZ_160 | Thrombomodulin (recombinant) | InVivo Biotech products available at Bio-Connect

Thrombomodulin (recombinant) | RP_SZ_160 | InVivo Biotech

Thrombomodulin (recombinant)

Recombinant form of the extracellular domain of Human Thrombomodulin which is produced under serum-free conditions in HEK 293 (human embryonic kidney) cells. The expression construct contains residues 1 to 515 of UniProt entry P07204: M406L, S492A. The M406L substitution (M388L in the mature protein) leads to a Thrombomodulin variant that resists oxidative inactivation [1]. The S492A substitution (Ser474 in the mature protein) removes an O-glycosylation site for chondroitin sulfate, a glycosaminoglycan (GAG) that increases anticoagulant activity [2, 3]. The recombinant protein is produced under serum-free conditions in optimized HEK293-cell system and purified through one-step purification with ion exchange chromatography.

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