BMH-22 [309726-06-5]

MedChem Express

BMH-22 [309726-06-5]

14

309726-06-5

Research Use Only

C16H17N3

251.33

BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].

CC1=C2N=C3N=C(C=C(C3=C(C2=CC(C)=C1)N)C)C

12352200