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BMP-2, Human/Mouse/Rat (Tag Free)

HY-P7006B
MedChem Express
Protein IDP12643
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    MedChem Express
  • Product Name
    BMP-2, Human/Mouse/Rat (Tag Free)
  • Delivery Days Customer
    14
  • Certification
    Research Use Only
  • Estimated Purity
    98.00
  • Protein IDP12643
  • Protein Name
    Bone morphogenetic protein 2
  • Scientific Description
    Bone morphogenetic protein 2 (BMP-2) is a pleiotropic ligand protein belonging to TNFbeta family, and is involved in key embryonic development of vascular and valvular homeostasis. BMP-2 binds to type I receptors (ALK-2/-3/-6) and type II receptors (BMPR2, ACVR2A) to regulate various types of calcification, including atherosclerosis, chronic kidney disease, diabetes, and valve calcification[1]. BMP-2 is overexpressed by myofibroblast and preosteoblast in the calcified area of human calcified valve, which are densely infiltrated by B lymphocytes and T lymphocytes[2]. BMP-2 is the junction between atherosclerotic vascular calcification and normal bone formation mechanism[3]. BMP-2 Protein, Human/Mouse/Rat is 104 a.a. (Q283-R396), expressed in E. coli.
  • Storage Instruction
    -20°C
  • UNSPSC
    12352202

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