BMS-284640 [230640-88-7]

MedChem Express

BMS-284640 [230640-88-7]

10

230640-88-7

Research Use Only

C15H19N3O2

273.33

BMS-284640 is a synthetic sodium hydrogen exchange isomer-1 (NHE-1) inhibitor. BMS-284640 has a more than 380-fold higher NHE-1 inhibitory activity (IC50: 9 nM) compared to cariporide (HY-19693) and is more selective for NHE-1 over NHE-2 (IC50: 1.8 microM) and NHE-5 (IC50: 3.36 microM). BMS-284640 and its analogs also exhibit enhanced oral bioavailability and prolonged plasma half-life in rats.[1].

O=C([C@H]1C(C)(C)[C@@H]1C2=C3CCOC3=CC=C2)NC(N)=N

4°C (Powder, sealed storage, away from moisture and light)

12352200