BMS-358233 [601519-75-9]
HY-120625
CAS Number601519-75-9
Product group Chemicals
Molecular Weight509.02
Overview
- SupplierMedChem Express
- Product NameBMS-358233 [601519-75-9]
- Delivery Days Customer5
- CAS Number601519-75-9
- CertificationResearch Use Only
- Molecular FormulaC25H25ClN6O2S
- Molecular Weight509.02
- Scientific DescriptionPU3 is a small molecule inhibitor of Hsp90 that competes with geldanamycin for Hsp90. PU3 induces degradation of proteins, including Her2, similar to geldanamycin. PU3 inhibits the growth of breast cancer cells, causing retinoblastoma protein hypophosphorylation, G1 arrest, and differentiation. PU3 represents a novel class of synthetic compounds that bind to Hsp90 and inhibit the proliferation of cancer cells. PU3 could provide a new strategy for the treatment of cancers[1].
- SMILESO=C(C1=CC=C2N=C(NC3=NC(NC[C@@H]4OCCC4)=NC(C)=C3)SC2=C1)NC5=C(C)C=CC=C5Cl
- UNSPSC12352200