BMS-599626

MedChem Express

BMS-599626 [714971-09-2]

10

714971-09-2

Research Use Only

C27H27FN8O3

530.55

BMS-599626 (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC 50 s of 20 and 30 nM, respectively. BMS-599626 displays ~8-fold less potent to HER4 (IC 50 =190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy [1] [2] .

O=C(NC1=CN2C(C(NC3=CC4=C(N(CC5=CC=CC(F)=C5)N=C4)C=C3)=NC=N2)=C1C)OC[C@H]6NCCOC6

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