BMS-708163 (Avagacestat) --- gamma-Secretase Inhibitor

Bioss

BMS-708163 (Avagacestat) --- gamma-Secretase Inhibitor [1146699-66-2]

16

Research Use Only

98.0

BMS-708163 (Avagacestat) is a potent, selective and orally bioavailable gamma-secretase inhibitor with an IC50 of 0.3 nM for APP cleavage. It is 190-fold more selective for APP than Notch, having an IC50 of 58 nM for Notch. Phase I clinical trial studies showed that in humans, BMS-708163 decreased CSF Abeta40 and Abeta42 approximately 30% following daily dose of 100 mg after 28 days and by 60% at daily dose of 150 mg.

-20°C

51202000