BMS-935177

AbMole BioScience

BMS-935177

9

1231889-53-4

Chemical

Research Use Only

C31H26N4O3

502.56

BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.

CC1=C(C=CC=C1C2=CC=C(C(N)=O)C3=C2C4=C([NH]3)C=C(C=C4)C(C)(C)O)N5C=NC6=C(C=CC=C6)C5=O

12352200