BMS-986202 [1771691-34-9]

MedChem Express

BMS-986202 [1771691-34-9]

10

1771691-34-9

Research Use Only

99.29

C22H18D3FN6O3

439.46

BMS-986202 is a potent, selective and orally active Tyk2 inhibitor that binds to Tyk2 JH2 with an IC50 value of 0.19 nM and a Ki of 0.02 nM. BMS-986202 is remarkably selective over other kinases including Jak family members. BMS-986202 is also a weak inhibitor of CYP2C19 with an IC50 value of 14 microM. BMS-986202 can be used for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus research. BMS-986202 is a de novo deuterium[1].

O=C(NC1=NC=C(C(NC2=CC=CC(C3=NC=C(C=N3)F)=C2OC)=C1)C(NC([2H])([2H])[2H])=O)C4CC4

-20°C,2°C to 8°C

12352200