BMS-986251

MedChem Express

BMS-986251

10

2460133-35-9

Research Use Only

C30H29F8NO5S

667.61

BMS-986251 is an orally active and selective RORgammat inverse agonist with an EC 50 of 12 nM for RORgammat GAL4. BMS-986251 inhibits IL-17 with an EC 50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced (HY-B0180) models (preclinical models of psoriasis) [1] .

O=C([C@H]1C[C@H](C)[C@H](C(N2CC[C@@]3(S(=O)(C4=CC=C(F)C=C4)=O)C5=CC=C(C(C(F)(F)F)(F)C(F)(F)F)C=C5CC[C@@]23[H])=O)CC1)O

12352200