BMS-986251 [2460133-35-9]

TargetMol Chemicals

BMS-986251 [2460133-35-9]

999

2460133-35-9

Chemical

Research Use Only

BMS-986251

C30H29F8NO5S

667.61

BMS-986251 is a potent and specific RORgammat inverse agonist that exerts its action via oral administration. It shows an EC 50 of 12 nM for RORgammat GAL4. In human whole blood assay, BMS-986251 effectively inhibits IL-17 with an EC 50 of 24 nM. Furthermore, BMS-986251 exhibits strong therapeutic effects in mouse acanthosis and Imiquimod-induced models, which are commonly used preclinical models for psoriasis.

3 years

[H][C@@]12CCc3cc(ccc3[C@@]1(CCN2C(=O)[C@@H]1CC[C@H](C[C@@H]1C)C(O)=O)S(=O)(=O)c1ccc(F)cc1)C(F)(C(F)(F)F)C(F)(F)F

-20°C

12352200