BMY 7378 (free base) [21102-94-3]

MedChem Express

BMY 7378 (free base) [21102-94-3]

5

21102-94-3

Research Use Only

C22H31N3O3

385.50

BMY 7378 (free base) is a selective antagonist of alpha1D-adrenoceptor (alpha1D-AR). BMY 7378 (free base) binds to membranes expressing the cloned rat alpha1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat alpha1A-AR (Ki=800 nM) or the hamster alpha1B-AR (Ki=600 nM). BMY 7378 (free base) is a 5-HT1A receptor partial agonist[1][2].

O=C(N(CCN1CCN(C2=CC=CC=C2OC)CC1)C(C3)=O)CC43CCCC4

12352200