BO-264

MedChem Express

BO-264 [2408648-20-2]

9

2408648-20-2

Research Use Only

99.63

C18H19N5O3

353.38

BO-264 is a highly potent and orally active transforming acidic coiled-coil 3 (TACC3) inhibitor with an IC 50 of 188 nM and a K d of 1.5 nM. BO-264 specifically blocks the function of FGFR3-TACC3 fusion protein. BO-264 induces spindle assembly checkpoint (SAC)-dependent mitotic arrest, DNA damage and apoptosis . BO-264 has broad-spectrum antitumor activity [1] .

COC1=CC=C(C2=NOC(NC3=NC(N4CCOCC4)=NC=C3)=C2)C=C1

-20°C,2°C to 8°C

12352200