BOLD-100 (free base) [783324-98-1]

MedChem Express

BOLD-100 (free base) [783324-98-1]

10

783324-98-1

Research Use Only

C14H12Cl4N4Ru

479.15

BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].

[Cl-][Ru+4]([Cl-])([Cl-])([N]1=CC2=CC=CC=C2N1)([N]3=CC4=CC=CC=C4N3)[Cl-]

12131703