Borrelidin

MedChem Express

Borrelidin [7184-60-3]

10

7184-60-3

Research Use Only

99.80

C28H43NO6

489.64

Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei [1] . Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC 50 of 24 microM [2] . Borrelidin is a potent angiogenesis inhibitor, with an IC 50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells [3] . Borrelidin has strong antimalarial activities, with IC 50 s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum , respectively [4] .

O=C([C@H]1[C@H]([C@H](C/C=C/C=C(C#N)\[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)C2)OC2=O)CCC1)O

-20°C

12352200