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Borrelidin

HY-N6742
MedChem Express
CAS Number7184-60-3
Product group Chemicals
Estimated Purity99.80
Molecular Weight489.64
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Borrelidin [7184-60-3]
  • Delivery Days Customer
    10
  • CAS Number
    7184-60-3
  • Certification
    Research Use Only
  • Estimated Purity
    99.80
  • Molecular Formula
    C28H43NO6
  • Molecular Weight
    489.64
  • Scientific Description
    Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei [1] . Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC 50 of 24 microM [2] . Borrelidin is a potent angiogenesis inhibitor, with an IC 50 of 0.8 nM. Borrelidin induces apoptosis in the tube-forming cells [3] . Borrelidin has strong antimalarial activities, with IC 50 s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum , respectively [4] .
  • SMILES
    O=C([C@H]1[C@H]([C@H](C/C=C/C=C(C#N)\[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)C2)OC2=O)CCC1)O
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

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Product group Chemicals
TargetMol Chemicals
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Molecular Weight489.64
  • SizePrice