Bortezomib

MedChem Express

Bortezomib [179324-69-7]

10

179324-69-7

Research Use Only

99.97

C19H25BN4O4

384.24

Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome ( K i =0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-kappaB . Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity [1] [2] .

OB(O)[C@H](CC(C)C)NC([C@@H](NC(C1=NC=CN=C1)=O)CC2=CC=CC=C2)=O

2°C to 8°C

12352200