Bortezomib-d8

MedChem Express

Bortezomib-d8

10

Research Use Only

98.0

C19H17D8BN4O4

392.29

Bortezomib-d 8 is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-kappaB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity[1][2].

OB([C@H](CC(C)C)NC(C(NC(C1=NC=CN=C1)=O)([2H])C([2H])([2H])C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)O

-20°C

12352200