BPIQ-II (hydrochloride) [171179-37-6]

MedChem Express

BPIQ-II (hydrochloride) [171179-37-6]

5

171179-37-6

Research Use Only

C15H11BrClN5

376.64

BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50=8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.

BrC1=CC(NC2=NC=NC3=C2C=C4NC=NC4=C3)=CC=C1.Cl

12352200