BPN-15606

MedChem Express

BPN-15606 [1914989-49-3]

9

1914989-49-3

Research Use Only

99.96

C23H23FN6O

418.47

BPN-15606 is a highly potent, orally active gamma-secretase modulator (GSM), attenuates the production of Abeta42 and Abeta40 by SHSY5Y neuroblastoma cells with IC 50 values of 7 nM and 17nM, respectively. BPN-15606 lowers Abeta42 and Abeta40 levels in the central nervous system of rats and mice. BPN-15606 has acceptable PK/PD properties, including bioavailability, half-life, and clearance [1] .

CC1=CC(C2=NC(OC)=C(N3C=C(C)N=C3)C=C2)=NN=C1N[C@H](C4=CC=C(F)C=C4)C

-20°C

12352200