BRAFV600E/JNK-IN-1

MedChem Express

BRAFV600E/JNK-IN-1

5

Research Use Only

C24H25ClN6O3S

513.01

BRAFV600E/JNK-IN-1 (Compound 14c) is an inhibitor of JNK1, JNK2, JNK3 and BRAFV600E, with IC50 values of 0.51 microM, 0.53 microM, 1.02 microM and 0.009 microM, respectively. BRAFV600E/JNK-IN-1 can inhibit the phosphorylation of MEK1/2 and ERK1/2. In addition, BRAFV600E/JNK-IN-1 can inhibit tumor cell proliferation, NO release and PGE2 production, and has anti-tumor and anti-inflammatory activities[1].

OC1=CC(C2=NN(CC)C=C2C3=CC=NC(NCCCNS(=O)(C4=CC=C(Cl)C=C4)=O)=N3)=CC=C1

12352200