Branaplam [1562338-42-4]
HY-19620
CAS Number1562338-42-4
Product group Chemicals
Estimated Purity95.62%
Molecular Weight393.48
Overview
- SupplierMedChem Express
- Product NameBranaplam [1562338-42-4]
- Delivery Days Customer10
- CAS Number1562338-42-4
- CertificationResearch Use Only
- Estimated Purity95.62%
- Molecular FormulaC22H27N5O2
- Molecular Weight393.48
- Scientific DescriptionBranaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 microM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.
- SMILESOC1=CC(C2=CNN=C2)=CC=C1C3=CC=C(OC4CC(C)(C)NC(C)(C)C4)N=N3
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200