BRAP Antibody

Cusabio

BRAP Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

BRAP

BRCA1 associated protein

BRAP2; BRCA1-associated protein; galectin-2-binding protein; IMP; impedes mitogenic signal propagation; renal carcinoma antigen NY-REN-63; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; RNF52

Rabbit

IgG

BRCA1-associated protein

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Human, Rat

-20°C or -80°C

41116161