BRCA2 antibody [5F6]

GeneTex

BRCA2 antibody [5F6]

9

Do not boil samples for longer than two minutes. For WB: Use at a concentration of 1-5 microg/ml. Predicted molecular weight: 380 kDa. Optimal dilutions/concentrations should be determined by the reseracher.

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

5F6

1 mg/ml

Unconjugated

BRCA2

BRCA2 DNA repair associated

BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer type 2 susceptibility protein, BRCA1/BRCA2-containing complex, subunit 2, BRCA2 DNA repair associated protein, DNA repair-associated BRCA2, Fanconi anemia group D1 protein, breast and ovarian cancer susceptibility gene, early onset, breast and ovarian cancer susceptibility protein 2, breast cancer 2 tumor suppressor, breast cancer 2, early onset, mutant BRCA2, mutant DNA repair-associated protein 2

Mouse

IgG1

Breast cancer type 2 susceptibility protein

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203