BRD3308

AbMole BioScience

BRD3308

9

1550053-02-5

Chemical

Research Use Only

C15H14FN3O2

287.29

BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23 times more selective to HDAC3 than HDAC1 (IC50:1.26 uM) or HDAC2 (IC50:1.34 uM). BRD3308 inhibits pancreatic bèta cell apoptosis induced by inflammatory cytokines or glucolipid toxic stress and increases functional insulin release. BRD3308 also activates HIV-1 transcription and disrupts HIV-1 latency.

CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=C(F)C=C2N

12352200