BRD5648 [2056261-42-6]

MedChem Express

BRD5648 [2056261-42-6]

10

2056261-42-6

Research Use Only

99.94

C20H23N3O

321.42

BRD5648 ((R)-BRD0705) is a negative control of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3alpha inhibitor with an IC50 of 66 nM and a Kd of 4.8 microM. BRD0705 displays increased selectivity for GSK3alpha (8-fold) versus GSK3beta (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2].

O=C1C2=C(N=C3C([C@@]2(CC)C4=CC=CC=C4)=CNN3)CC(C)(C)C1

-20°C,2°C to 8°C

12352200