Brevetoxin B

MedChem Express

Brevetoxin B [79580-28-2]

10

79580-28-2

Research Use Only

C50H70O14

895.08

Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels ( IC 50 =15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.

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