Brexpiprazole

MedChem Express

Brexpiprazole [913611-97-9]

10

913611-97-9

Research Use Only

99.85

C25H27N3O2S

433.57

Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D 2L receptor with K i s of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a K i of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic alpha 1B (K i =0.17 nM) and alpha 2C receptors (K i =0.59 nM) [1] [2] .

O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C(C=CS5)C5=CC=C4)CC3)=C2)C=C1

-20°C,2°C to 8°C

12352200