Brexpiprazole [913611-97-9]

MedChem Express

Brexpiprazole [913611-97-9]

10

913611-97-9

Research Use Only

99.85

C25H27N3O2S

433.57

Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic alpha1B (Ki=0.17 nM) and alpha2C receptors (Ki=0.59 nM)[1][2].

O=C1NC2=C(C=CC(OCCCCN3CCN(C4=C(C=CS5)C5=CC=C4)CC3)=C2)C=C1

-20°C,2°C to 8°C

12352200