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Brn2 antibody

Research Use Only
GTX114650
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Primate, Rat
TargetPOU3F2
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Overview

  • Supplier
    GeneTex
  • Product Name
    Brn2 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IHC-Fr: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.2 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID5454
  • Target name
    POU3F2
  • Target description
    POU class 3 homeobox 2
  • Target synonyms
    brain-2; brain-specific homeobox/POU domain protein 2; BRN2; brn-2; nervous system-specific octamer-binding transcription factor N-Oct-3; N-Oct3; OCT7; oct-7; octamer-binding protein 7; octamer-binding transcription factor 7; OTF7; OTF-7; POU domain, class 3, transcription factor 2; POUF3
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP20265
  • Protein Name
    POU domain, class 3, transcription factor 2
  • Scientific Description
    POU3F2 belongs to a large family of transcription factors that bind to the octameric DNA sequence ATGCAAAT. Most of these proteins share a highly homologous region, referred to as the POU domain, that occurs in several mammalian transcription factors, including the octamer-binding proteins Oct1 (POU2F1; MIM 164175) and Oct2 (POU2F2; MIM 164176) and the pituitary protein Pit1 (PIT1; MIM 173110). Class III POU genes are expressed predominantly in the central nervous system (CNS). It is likely that CNS-specific transcription factors such as these play an important role in mammalian neurogenesis by regulating their diverse patterns of gene expression (Schreiber et al., 1993 [PubMed 8441633]; Atanasoski et al., 1995 [PubMed 7601453]).[supplied by OMIM]
  • Reactivity
    Human, Mouse, Primate, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • WDFY3 mutation alters laminar position and morphology of cortical neurons. Schaaf ZA et al., 2022 Jun 22, Mol Autism
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  • Hierarchical reactivation of transcription during mitosis-to-G1 transition by Brn2 and Ascl1 in neural stem cells. Soares MAF et al., 2021 Jul 1, Genes Dev
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  • Loss of CC2D1A in Glutamatergic Neurons Results in Autistic-Like Features in Mice. Yang CY et al., 2021 Jul, Neurotherapeutics
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  • Talpid3-Mediated Centrosome Integrity Restrains Neural Progenitor Delamination to Sustain Neurogenesis by Stabilizing Adherens Junctions. Wang J et al., 2020 Dec 15, Cell Rep
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  • Nwd1 Regulates Neuronal Differentiation and Migration through Purinosome Formation in the Developing Cerebral Cortex. Yamada S et al., 2020 May 22, iScience
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  • Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells. Kitajima R et al., 2020 Apr, Stem Cell Res
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  • Reliability of human cortical organoid generation. Yoon SJ et al., 2019 Jan, Nat Methods
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  • Discovery of novel determinants of endothelial lineage using chimeric heterokaryons. Wong WT et al., 2017 Mar 21, Elife
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  • DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis. Enriquez-Rios V et al., 2017 Jan 25, J Neurosci
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  • Insulinoma-Associated Protein 1 Is a Crucial Regulator of Neuroendocrine Differentiation in Lung Cancer. Fujino K et al., 2015 Dec, Am J Pathol
    Read more