BTTAA, 2-(4-((bis((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)amino)methyl)-1H-1,2,3-triazol-1-yl)acetic acid

Jena Bioscience

BTTAA, 2-(4-((bis((1-(tert-butyl)-1H-1,2,3-triazol-4-yl)methyl)amino)methyl)-1H-1,2,3-triazol-1-yl)acetic acid

5

Research Use Only

>95%

C19H30N10O2

430.51 g/mol

BTTAA is a water-soluble, very effective ligand for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). It serves a dual purpose: 1) Accelaration of the CuAAC reaction by maintaining the Cu(I) oxidation state of copper sources and 2) Protection of biomolecules from oxidative damage during the labeling reaction[1,2]. BTTAA is a superior alternative to water-insoluble TBTA. A stock solution can be prepared in ddH2O and subsequently be stored at -20°C. Avoid freeze-thaw cycles. Presolski et al.[3] and Hong et al.[4] provide a general protocol for CuAAC reactions that may be used as a starting point for the set up and optimization of individual assays.

N(Cc1nnn(c1)C(C)(C)C)(Cc1nnn(c1)CC(=O)O)Cc1cn(nn1)C(C)(C)C

-20°C

12352200