Bumetanide

MedChem Express

Bumetanide [28395-03-1]

10

28395-03-1

Research Use Only

99.95

C17H20N2O5S

364.42

Bumetanide (Ro 10-6338; PF 1593), a highly potent loop diuretic, is a Na+-K+-Cl+ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC50s of 0.68 microM and 4.0 microM for hNKCC1A and hNKCC2A, respectively[1][2].

O=C(O)C1=CC(NCCCC)=C(OC2=CC=CC=C2)C(S(=O)(N)=O)=C1

2°C to 8°C

12352200